Dr. Chan joined the Athinoula A. Martinos Center for Biomedical Imaging at MGH in 2010 as an instructor. Her current research focuses on imaging of cerebrovascular responses using ultrasound and MRI. She uses natural breathing/gaseous challenge to measure cerebrovascular responses in healthy subjects, patients with episodic migraine, traumatic brain injury, Huntington’s disease, atrial fibrillation and chronic fatigue syndrome. She has developed a robust physiological model for the assessment of cerebrovascular reactivity under brief breath hold challenge. Her model has been tested on patients to localize subtle cerebrovascular changes for disease diagnosis and monitoring of disease progression.
Education
PhD in Radiography/Ultrasound, Hong Kong Polytechnic University
Select Publications
Chan ST, Brook F, Ahuja A, Brown B, Metreweli C. Relationship of thyroid blood flow to reproductive events in normal Chinese females. Ultrasound Med Biol. 1999 Feb;25(2):233-40. doi: 10.1016/s0301-5629(98)00145-8. PMID: 10320312.
Chan ST, Tam Y, Lai CY, Wu HY, Lam YK, Wong PN, Kwong KK. Transcranial Doppler study of cerebrovascular reactivity: are migraineurs more sensitive to breath-hold challenge? Brain Res. 2009 Sep 29;1291:53-9. doi: 10.1016/j.brainres.2009.07.057. Epub 2009 Jul 25. PMID: 19635466.
Chan ST, Evans KC, Song TY, Selb J, van der Kouwe A, Rosen BR, Zheng YP, Ahn A, Kwong KK. Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge. PLoS One. 2020 Mar 24;15(3):e0225915. doi: 10.1371/journal.pone.0225915. PMID: 32208415.
Highlights
Over 40 peer-reviewed journal articles