Dr. Iris Yuwen Zhou is an Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School and a faculty member in the Athinoula A. Martinos Center for Biomedical Imaging. She has a background in both electronic engineering and biomedical engineering, with specific training in research areas for magnetic resonance imaging (MRI). Her work focuses on developing novel MRI methodologies that quantify molecular, metabolic, functional, and structural alterations for stroke, fibrosis, and tumor imaging. Her research spans tissue characterization using molecularly targeted probes, chemical exchange saturation transfer (CEST), diffusion, functional MRI in animal models and clinical translation. More recently, her research topics also include the integration of multi-parametric MRI data with information from other imaging modalities, such as positron emission tomography (PET), through leveraging advances in multi-modal imaging, chemistry, data modeling, and image analysis. Her research is currently funded by an NIH-NHLBI K25 Grant. Her overall goal is to develop novel imaging approaches that quantify structural, physiological, and functional abnormalities in lung and liver diseases for improved diagnosis, and to deploy these techniques in clinical trials to accelerate the development of new therapeutics.
Education
PhD in Biomedical Engineering, The University of Hong Kong
Select Publications
1. Zhou IY, Ramsay IA, Ay I, Pantazopoulos P, Rotile NJ, Wong A, Caravan P, Gale EM. (2021) Positron Emission Tomography-Magnetic Resonance Imaging Pharmacokinetics, In Vivo Biodistribution, and Whole-Body Elimination of Mn-PyC3A. Invest Radiol 56(4):261-70.
2. Zhou IY, Clavijo Jordan V, Rotile NJ, Akam E, Krishnan S, Arora G, Krishnan H, Slattery H, Warner N, Mercaldo N, Farrar CT, Wellen J, Martinez R, Schlerman F, Tanabe KK, Fuchs BC, Caravan P. Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis. Radiology. 2020 Apr 28;296(1):67-75
3. Zhou IY, Wang E, Cheung JS, Zhang X, Fulci G, Sun PZ. Quantitative chemical exchange saturation transfer (CEST) MRI of glioma using Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting. Sci Rep. 2017 Mar 7;7(1):84.
4. Zhou IY, Liang YX, Chan RW, Gao PP, Cheng JS, Hu Y, So KF, Wu EX. Brain resting-state functional MRI connectivity: morphological foundation and plasticity. Neuroimage. 2014 Jan 1;84:1-10.
Highlights
Young Investigator Award, CMITT, SNMMI 2020
K25 Mentored Quantitative Research Career Development Award, NIH/NHLBI
Over 50 peer-reviewed journal articles, 3 issued patents
Summa Cum Laude Merit Award, ISMRM-ESMRMB 2014