Dr. Hui Wang’s research interests include developing innovative optical techniques and combining with MRI to study the structural-functional relationship of the brain. Particularly, a key question to answer is how the brain is connected to form the substrates of complex functions and what goes wrong in brain diseases. She has developed novel polarization sensitive optical coherence tomography techniques for mapping the connectivity and associated neuronal architecture in ex-vivo human brains and investigating in-vivo neurovascular coupling in small animals at micrometer resolution. Using the techniques, She has been studying the circuitry and architecture disruptions with neurodegenerative diseases in the cerebrum and the cerebellum. By incorporating high-resolution microscopic images into MRI tools, the goal is to identify pathology-related alterations as potential diagnostic biomarkers and prospective therapeutic targets.
Education
PhD, University of Minnesota
Select Publications
1. Wang H, Magnain C, Wang R, Dubb J, Varjabedian A, Tirrell LS, Stevens A, Augustinack JC, Konukoglu E, Aganj I, Frosch MP, Schmahmann JD, Fischl B, Boas DA. as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity. Neuroimage. 2018 Jan 15;165:56-68.
2. Wang H, Magnain C, Sakadžić S, Fischl B, Boas DA. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography. Biomed Opt Express. 2017 Nov 14;8(12):5617-5636.
3. Wang H, Akkin T, Magnain C, Wang R, Dubb J, Kostis WJ, Yaseen MA, Cramer A, Sakadžić S, Boas D. Polarization sensitive optical coherence microscopy for brain imaging. Opt Lett. 2016 May 15;41(10):2213-6.
Highlights
2018: NIH K99/R00 Pathway to Independence Career Development Award
2016: UT Brain Seed Grant
2012: Doctoral Dissertation Fellowship at the University of Minnesota