Dr. Bertrand Thirion, INRIA/CEA/Neurospin France

Abstract:

To map the neural substrate of mental function, cognitive neuroimaging relies on controlled psychological manipulations that engage brain systems associated with specific cognitive processes. In order to build comprehensive atlases of cognitive function in the brain, it must assemble maps for many different cognitive processes, which often evoke overlapping patterns of activation. Such data aggregation faces contrasting goals: on the one hand finding correspondences across vastly different cognitive experiments, while on the other hand precisely describing the function of any given brain region. In this talk I will present two analysis frameworks that tackle these difficulties and thereby enable the generation of brain atlases for cognitive function.  The first one uses deep-learning techniques to extract representations—task-optimized networks—that form a set of basis cognitive dimensions relevant to the psychological manipulations.This approach does not assume any prior knowledge of the commonalities shared by the studies in the corpus; those are inferred during model training. The second one leverages ontologies of cognitive concepts and multi-label brain decoding to map the neural substrate of these concepts. Crucially, it can accurately decode the cognitive concepts recruited in new tasks. These results demonstrate that aggregating independent task-fMRI studies can provide a more precise global atlas of selective associations between brain and cognition.

Bio:

Bertrand Thirion is the leader of the Parietal team, part of INRIA research institute, Saclay, France, that develops statistics and machine learning techniques for brain imaging. He contributes both algorithms and software, with a special focus on functional neuroimaging applications. He is involved in the Neurospin (CEA) neuroimaging center, one of the leading high-field MRI for brain imaging places. Bertrand Thirion is also head of the DATAIA  Institute that federates research on AI, data science and their societal impact in Paris-Saclay University. He has recently been appointed as member of the expert committee in charge of advising the government during the Covid-19 pandemic.

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Speaker

Dr. Bertrand Thirion, INRIA/CEA/Neurospin France