Extracting the time series of activations in a label¶

We first apply a dSPM inverse operator to get signed activations in a label (with positive and negative values) and we then compare different strategies to average the times series in a label. We compare a simple average, with an averaging using the dipoles normal (flip mode) and then a PCA, also using a sign flip.

Out:

Reading /home/circleci/mne_data/MNE-sample-data/MEG/sample/sample_audvis-ave.fif ...
Read a total of 4 projection items:
PCA-v1 (1 x 102) active
PCA-v2 (1 x 102) active
PCA-v3 (1 x 102) active
Average EEG reference (1 x 60) active
Found the data of interest:
t =    -199.80 ...     499.49 ms (Left Auditory)
0 CTF compensation matrices available
nave = 55 - aspect type = 100
Projections have already been applied. Setting proj attribute to True.
Applying baseline correction (mode: mean)
Reading inverse operator decomposition from /home/circleci/mne_data/MNE-sample-data/MEG/sample/sample_audvis-meg-oct-6-meg-inv.fif...
[done]
[done]
305 x 305 full covariance (kind = 1) found.
Read a total of 4 projection items:
PCA-v1 (1 x 102) active
PCA-v2 (1 x 102) active
PCA-v3 (1 x 102) active
Average EEG reference (1 x 60) active
22494 x 22494 diagonal covariance (kind = 2) found.
22494 x 22494 diagonal covariance (kind = 6) found.
22494 x 22494 diagonal covariance (kind = 5) found.
Did not find the desired covariance matrix (kind = 3)
Computing patch statistics...
[done]
Computing patch statistics...
[done]
Read a total of 4 projection items:
PCA-v1 (1 x 102) active
PCA-v2 (1 x 102) active
PCA-v3 (1 x 102) active
Average EEG reference (1 x 60) active
Source spaces transformed to the inverse solution coordinate frame
Preparing the inverse operator for use...
Scaled noise and source covariance from nave = 1 to nave = 55
Created the regularized inverter
Created an SSP operator (subspace dimension = 3)
Created the whitener using a noise covariance matrix with rank 302 (3 small eigenvalues omitted)
Computing noise-normalization factors (dSPM)...
[done]
Applying inverse operator to "Left Auditory"...
Picked 305 channels from the data
Computing inverse...
Eigenleads need to be weighted ...
Computing residual...
Explained  59.4% variance
dSPM...
[done]
Extracting time courses for 1 labels (mode: mean)
Extracting time courses for 1 labels (mode: mean_flip)
Extracting time courses for 1 labels (mode: pca_flip)
Number of vertices : 33


# Author: Alexandre Gramfort <alexandre.gramfort@telecom-paristech.fr>
#

import matplotlib.pyplot as plt

import mne
from mne.datasets import sample

print(__doc__)

data_path = sample.data_path()
label = 'Aud-lh'
label_fname = data_path + '/MEG/sample/labels/%s.label' % label
fname_inv = data_path + '/MEG/sample/sample_audvis-meg-oct-6-meg-inv.fif'
fname_evoked = data_path + '/MEG/sample/sample_audvis-ave.fif'

snr = 3.0
lambda2 = 1.0 / snr ** 2
method = "dSPM"  # use dSPM method (could also be MNE or sLORETA)

evoked = mne.read_evokeds(fname_evoked, condition=0, baseline=(None, 0))
src = inverse_operator['src']

# Compute inverse solution
pick_ori = "normal"  # Get signed values to see the effect of sign filp
stc = apply_inverse(evoked, inverse_operator, lambda2, method,
pick_ori=pick_ori)

stc_label = stc.in_label(label)
modes = ('mean', 'mean_flip', 'pca_flip')
tcs = dict()
for mode in modes:
tcs[mode] = stc.extract_label_time_course(label, src, mode=mode)
print("Number of vertices : %d" % len(stc_label.data))

# View source activations
fig, ax = plt.subplots(1)
t = 1e3 * stc_label.times
ax.plot(t, stc_label.data.T, 'k', linewidth=0.5)
for mode, tc in tcs.items():
ax.plot(t, tc[0], linewidth=3, label=str(mode))
ax.legend(loc='upper right')
ax.set(xlabel='Time (ms)', ylabel='Source amplitude',
title='Activations in Label : %s' % label)


Total running time of the script: ( 0 minutes 1.348 seconds)

Estimated memory usage: 66 MB

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